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August 5, 2018 by Open Excellence

Micronutrient Study Actively Recruiting Eligible Children in Oregon, Ohio and Alberta, Canada

Oregon Health & Science University Collaborating with The Ohio State University and University of Lethbridge to Trial Micronutrients for Children with ADHD

(Portland, OR) – The first North American trial of a 36-ingredient micronutrient formula is underway at Oregon Health & Science University (OHSU), The Ohio State University (OSU) and at University of Lethbridge in Alberta, Canada. In only three months of recruiting, the Micronutrients in ADHD Youth (MADDY) Study has enrolled 40 participants among the three sites, nearly one-third of our target number. All three sites are actively recruiting eligible children to participate. The children must be off of psychotropic medication for at least two weeks prior to starting the study to meet entrance criteria. The study is supported by a grant from the Foundation for Excellence in Mental Health Care.

Children, ages 6-12 years of age, who have ADHD and some irritable mood symptoms are participating in an 8-week randomized controlled trial. During this phase, they will receive either the active product or a matching placebo. Neither the participants’ families nor the clinicians will know which one. After 8 weeks, all the children are eligible to receive the active product for a further eight weeks.  We are collecting data on the children’s mood and behavior at baseline and comparing their reports at the end of the treatment. We are also collecting blood, urine, stool, hair and saliva to begin looking at the biological basis for why some children benefit from taking the micronutrients and others do not. The MADDY Study is based on the research from Dr. Julia Rucklidge’s lab in New Zealand in which she found that the children with ADHD and irritable, angry moods reported the most benefit from the treatment.

Several of the families who have completed the initial 8 weeks report significant improvements in their child’s functioning. While we don’t know which pills they were taking (active or placebo), it is encouraging to hear the positive stories of improvement in mood and attention, reduced anger and an ability to get along better with friends. We hope to complete MADDY recruitment by early 2019.


Jeanette Johnstone, MFT, PhD 

Licensed Psychologist and Clinical Researcher

Department of Psychiatry, Division of Child & Adolescent Psychiatry

Oregon Health & Science University

Micronutrients in ADHD Youth, The MADDY Study for The MADDY Study

(503) 494-3700 voice mail

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