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September 7, 2013 by Hikaru Hori et al

Switching to antipsychotic monotherapy can improve attention and processing speed, and social activity in chronic schizophrenia patients

elsevierHikaru Hori, Reiji YoshimuraAsuka KatsukiAtsuko-Ikenouchi SugitaKiyokazu AtakeJun Nakamura

Department of Psychiatry, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka 8078555, Japan



This study sought to examine whether switching polypharmacy therapy to monotherapy would improve the cognitive function and social function of patients with schizophrenia.


Thirty-nine patients with schizophrenia who were receiving therapy with two antipsychotics were randomly divided into a switch to monotherapy group (switching group) and a polypharmacy continued group (continuing group). For the patients allocated to the switching group, the dose level of one of the two antipsychotic drugs was gradually reduced to zero. Psychotic symptoms, cognitive function and social function scale scores were assessed immediately before and 24 weeks after switching, and the time courses of these scores were compared between the two groups.


Compared with the continuing group, the switching group demonstrated significantly greater improvement in attention after switching (p = 0.02). Furthermore, the improvement in daily living (p = 0.038) and work skills (p = 0.04) was significantly greater in the switching group. In an analysis of the correlation among sub-items with respect to the degrees of improvement, a significant correlation was noted between improvement in executive function and improvement in daily living (r = −0.64, p = 0.005) and between improvement in work skills and improvement in attention (r = −0.51, p = 0.038).


In patients with schizophrenia receiving polypharmacy, switching to monotherapy resulted in improvements in attention. Furthermore, improvements in executive function led to improvements in daily living, and improvements in attention led to improvements in work skills. Thus, switching to monotherapy is a useful option.


  • BACS-J, Brief Assessment of Cognition in Schizophrenia, Japanese-language version;
  • LASMI, Life Assessment Scale for the Mentally III;
  • PANSS, Positive and Negative Syndrome Scale


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